Product Information
Name:ROCK2-IN-12
Brand:Targetmol
Description:ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:455.46
Formula:C23H18FN9O
Technical inquiry about: ROCK2-IN-12
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