Product Information
Name:SJ-300
Brand:Targetmol
Description:SJ-300 is a selective, orally active DKK3-LRP1 inhibitor capable of crossing the blood-brain barrier. It binds to mLRPIV with a Kd of 7.9 μM and inhibits the DKK3-mLRPIV complex with an IC50 of 3.2 μM, without affecting the interaction between Aβ and LRP1. In Alzheimer's disease models, SJ-300 restores Aβ clearance functionality, improves cognitive function, and reduces neuropathology by approximately 73.3% (Aβ plaque reduction). SJ-300 is suitable for research related to Alzheimer's disease.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:342.46
Formula:C20H27FN4
Technical inquiry about: SJ-300
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