CAS 1210357-06-4
:Formula:C20H27FN4
InChI:InChI=1S/C20H27FN4/c1-14-20(13-22-17-9-11-24(12-10-17)18-7-8-18)15(2)25(23-14)19-5-3-16(21)4-6-19/h3-6,17-18,22H,7-13H2,1-2H3
InChI key:DPUCRBUYLSIGPN-UHFFFAOYSA-N
SMILES:CC1=C(C(=NN1C2=CC=C(C=C2)F)C)CNC3CCN(CC3)C4CC4
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SJ-300
CAS:SJ-300 is a selective, orally active DKK3-LRP1 inhibitor capable of crossing the blood-brain barrier. It binds to mLRPIV with a Kd of 7.9 μM and inhibits the DKK3-mLRPIV complex with an IC50 of 3.2 μM, without affecting the interaction between Aβ and LRP1. In Alzheimer's disease models, SJ-300 restores Aβ clearance functionality, improves cognitive function, and reduces neuropathology by approximately 73.3% (Aβ plaque reduction). SJ-300 is suitable for research related to Alzheimer's disease.Formula:C20H27FN4Molecular weight:342.46
