Product Information
- Arachidonyl trifluoromethyl ketone, Arachidonyltrifluoromethane
- (6Z,9Z,12Z,15Z)-1,1,1-Trifluoro-6,9,12,15-heneicosatetraen-2-one
- (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
- 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosatetraen-2-one
- 6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)-
- 6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (all-Z)-
- AACOCF<sub>3</sub>
- An 20579
- Arachidonic acid trifluoromethyl ketone
- Arachidonyl trifluoromethyl ketone
- See more synonyms
- Arachidonyltrifluoromethane
- Atfmk
- Bm 162353
- L 734575
- Pacocf3
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 holds promise for cardiovascular disease research.
Chemical properties
Technical inquiry about: TM-T21681 AACOCF3
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