AK177
Ref. TM-T218761
Product Information
Name:AK177
Brand:Targetmol
Description:AK177 is an allosteric activator of IRE1α ribonuclease, exhibiting binding affinities of 480 nM for non-phosphorylated and 180 nM for phosphorylated IRE1α. It promotes concentration-dependent cleavage of XBP1 mRNA probes by IRE1α and stably binds its kinase domain. However, AK177 displays poor kinase selectivity, and due to inadequate membrane permeability, shows negligible downstream pathway activation and antiproliferative activity at the cellular level.
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Chemical properties
Technical inquiry about: AK177
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