Phenamil methanesulfonate

CAS: 1161-94-0

Ref. TM-T23148

Product Information

• Name: Phenamil methanesulfonate
• Synonyms: Phenamil
• Brand: Targetmol
• Description: Phenamil methanesulfonate is a potent analog of Amiloride that functions as a strong and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM, Phenamil methanesulfonate also acts as a competitive inhibitor of TRPP3 and suppressing TRPP3-mediated calcium transport with an IC50 of 140 nM in Ca2+ uptake assays. Phenamil methanesulfonate robustly activates BMP signaling to promote bone repair, supporting its use in cystic fibrosis lung disease, ion channel biology, and regenerative medicine research.

Chemical properties

• Molecular weight: 401.83
• Formula: C₁₃H₁₆ClN₇O₄S
• Purity: 98.33%
• Color/Form: Solid