TRP/TRPV Channel
TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.
Found 112 products for "TRP/TRPV Channel".
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TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Formula:C25H22F2N4O2Purity:99.79%Color and Shape:SolidMolecular weight:448.4646Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Formula:C26H42ClN3O4Purity:99.66% - 99.80%Color and Shape:SolidMolecular weight:496.08BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Formula:C23H21F3N4O2Purity:99.68% - 99.84%Color and Shape:SolidMolecular weight:442.4336IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Formula:C8H12INOPurity:99.76%Color and Shape:White SolidMolecular weight:265.091GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Formula:C16H14ClF3N4O2Purity:99.58%Color and Shape:SolidMolecular weight:386.76TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Formula:C13H12N2O4SPurity:99.74%Color and Shape:White SolidMolecular weight:292.31(Iso)-TRPV4 antagonist 5
CAS:(Iso)-TRPV4 antagonist 5 are selective oral TRPV4 blockers for pulmonary edema research.Formula:C25H27FN6O3Purity:99.23% - 99.63%Molecular weight:478.52PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Formula:C27H32ClF3N2O2Purity:98.39% - 98.88%Color and Shape:SolidMolecular weight:509.003CBP-1018
CAS:CBP-1018 is a peptide-drug conjugate (PDC) composed of a dual-targeting ligand for FRα/TRPV6, linked to Monomethylauristatin E. It holds promise for research in the field of breast cancer.Formula:C132H192N30O38SMolecular weight:2839.18(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Formula:C21H24N4OPurity:99.65% - 99.77%Color and Shape:White SolidMolecular weight:348.4415TRPV4 antagonist 5
CAS:TRPV4 antagonist 5(GSK2798745 derivatives) are solid-form derivatives of GSK2798745, selective TRPV4 blockers and antagonists for cardiac and respiratory disorders.Formula:C25H27PN6O3Purity:98.80% - 99.40%Color and Shape:Yellow SolidMolecular weight:478.53L-R4W2
CAS:Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.Formula:C46H71N21O6Purity:98%Color and Shape:SolidMolecular weight:1014.2CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Color and Shape:Odour SolidCyclic ADP-Ribose (ammonium salt)
Cyclic ADP-Ribose (ammonium salt) (cADPR) is an NAD⁺ metabolite that triggers Ca²⁺ release from ER stores via ryanodine receptors, relevant to inflammation research.Formula:C15H21N5O13P2·xNH3Color and Shape:White SolidTRPV1 antagonist 6
TRPV1 antagonist 6 (compound 51) is a modality-selective TRPV1 antagonist that exhibits antagonistic activity against capsaicin activation with an IC50 of 2.85 nM and demonstrates an inhibition rate of 28.48% against proton activation at a concentration of 3 µM.Formula:C26H28ClN5O3Molecular weight:493.18807TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Formula:C24H25F3N4OPurity:98.93%Color and Shape:SoildMolecular weight:442.4767RN-1665
CAS:RN-1665 is a potent and selective TRPV4 receptor antagonist.Formula:C20H24F5N3O3S2Purity:99.96%Color and Shape:SoildMolecular weight:513.54Oleoyl Serotonin
CAS:Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.Formula:C28H44N2O2Purity:99.88%Color and Shape:SolidMolecular weight:440.6612AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Formula:C11H12ClNOPurity:99.76% - 99.96%Color and Shape:SolidMolecular weight:209.67NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFormula:C21H12F6N4Purity:95.26%Color and Shape:White SolidMolecular weight:434.3372
