5-Hydroxy-1-methylhydantoin
CAS: 84210-26-4
Ref. TM-T28222
1mg | 143.00 € | ||
5mg | 313.00 € | ||
10mg | 460.00 € | ||
25mg | 736.00 € | ||
50mg | 1,046.00 € | ||
100mg | 1,391.00 € | ||
500mg | 2,767.00 € | ||
1ml*10 (DMSO) | 217.00 € |
Product Information
- HD-003, HD003, NZ419, NZ-419, HD 003, NZ 419
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.
Chemical properties
Technical inquiry about: TM-T28222 5-Hydroxy-1-methylhydantoin
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.