Estimated delivery in United States, on Tuesday 16 Jul 2024
Product Information
Name:
N-desmethyl Regorafenib N-oxide
Description:
N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.
Notice:
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Brand:
Targetmol
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Technical inquiry about: TM-T84977 N-desmethyl Regorafenib N-oxide
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