Pan-RAS-IN-6
Ref. TM-T89850
Product Information
Name:Pan-RAS-IN-6
Brand:Targetmol
Description:Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:837.08
Formula:C46H60N8O5S
Color/Form:Solid
Technical inquiry about: Pan-RAS-IN-6
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