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Bemcentinib-d8

Ref. TM-TMIT-0183

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Targetmol

Product Information

Name:Bemcentinib-d8
Synonyms:
  • R428-d8
  • BGB324-d8
Brand:Targetmol
Description:Bemcentinib-d8 (R428-d8) is the deuterium-labeled form of Bemcentinib. Bemcentinib (R428) is an orally active, selective Axl inhibitor with an IC50 of 14 nM. It inhibits cancer cell migration and invasion. In cells, its selectivity for Axl is over 100-fold greater than for Abl, and over 50- and 100-fold greater for the TAM family kinases Mer and Tyro3, respectively. Bemcentinib can prevent tumor spread in metastatic breast cancer models and extends survival.
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Chemical properties

Technical inquiry about: Bemcentinib-d8

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