2-Amino-6-((2,6-dioxopiperidin-3-yl)carbamoyl)benzoic Acid

CAS: 1001852-14-7

Ref. TR-A100185

Product Information

• Name: 2-Amino-6-((2,6-dioxopiperidin-3-yl)carbamoyl)benzoic Acid
• Synonyms: Benzoic acid, 2-amino-6-[[(2,6-dioxo-3-piperidinyl)amino]carbonyl]- (ACI), 2-Amino-6-[[(2,6-dioxo-3-piperidinyl)amino]carbonyl]benzoic acid (ACI)

Description

Applications 2-Amino-6-((2,6-dioxopiperidin-3-yl)carbamoyl)benzoic Acid is a metabolite of Pomalidomide, a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 291.259
• Formula: C₁₃H₁₃N₃O₅
• Color/Form: Neat
• InChI: InChI=1S/C13H13N3O5/c14-7-3-1-2-6(10(7)13(20)21)11(18)15-8-4-5-9(17)16-12(8)19/h1-3,8H,4-5,14H2,(H,15,18)(H,20,21)(H,16,17,19)
• InChI key: InChIKey=WUCFRUNKXKEODY-UHFFFAOYSA-N
• SMILES: Nc1cccc(C(=O)NC2CCC(=O)NC2=O)c1C(=O)O