Alectinib-d8

CAS: 1256585-15-5

Ref. TR-A521182

Product Information

• Name: Alectinib-d8
• Synonyms: 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl-2,2,3,3,5,5,6,6-d8)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

Description

Applications Alectinib-d8 is the labelled analogue of Alectinib (C183365, HCl), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. Also is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
References Sakamoto, H., et al.: Cancer Cell., 19, 679 (2011); Kinoshita, K., et al.: Bio-org. Medn., 20, 1271 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 490.66
• Formula: C₃₀D₈H₂₆N₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3/i11D2,12D2,13D2,14D2
• InChI key: InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N
• SMILES: [2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(C2CCN(c3cc4c(cc3CC)C(=O)c3c([nH]c5cc(C#N)ccc35)C4(C)C)CC2)C1([2H])[2H]