2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester

CAS: 6966-01-4

Ref. TR-A601863

Product Information

• Name: 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester
• Synonyms: 2-Pyrazinecarboxylic acid, 3-amino-6-bromo-, methyl ester, Pyrazinecarboxylic acid, 3-amino-6-bromo-, methyl ester (9CI), 3-Amino-6-bromo-2-pyrazinecarboxylic acid methyl ester, Methyl 3-amino-6-bromopyrazine-2-carboxylate, NSC 18700, 5-Amino-2-Bromo-6-Pyrazinecarboxylic Acidmethyl Ester, 3-Amino-6-bromopyrazine-2-carboxylic acid methyl ester, Methyl 6-Bromo-3-aminopyrazine-2-carboxylic ester, Methyl 3-amino-6-bromopyrazine-2-carboxylic ester

Description

Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 232.03
• Formula: C₆H₆BrN₃O₂
• Color/Form: Neat
• InChI: InChI=1S/C6H6BrN3O2/c1-12-6(11)4-5(8)9-2-3(7)10-4/h2H,1H3,(H2,8,9)
• InChI key: InChIKey=CNXSIRHOIFRMOB-UHFFFAOYSA-N
• SMILES: COC(=O)c1nc(Br)cnc1N