A77 1726 (E/Z) Mixture

CAS: 108605-62-5

Ref. TR-A771720

Product Information

• Name: A77 1726 (E/Z) Mixture
• Synonyms: 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide, 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, (EZ)-Teriflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide, (2Z)-2-(hydroxy{[4-(trifluoromethyl)phenyl]amino}methylidene)-3-oxobutanenitrile, (Z)-2-Cyano-alpha'alpha'alpha-trifluoro-3-hydroxy-p-crotonotoluidide, 2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-, 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide, A 771726, A771726, Active metabolite of leflunomide, Flucyamide, Hmr 1726, Malononitrilamide, N-(4-Trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide, Su 20, Teriflunomide, Teriflunomide [INN], Unii-1C058Ikg3B

Description

Impurity Leflunomide USP Related Compound B
Applications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 270.21
• Formula: C₁₂H₉F₃N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)
• SMILES: C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1