A77 1726 (E/Z) Mixture

CAS: 108605-62-5

Ref. TR-A771720

Product Information

• Name: A77 1726 (E/Z) Mixture
• Synonyms: 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide, 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, (EZ)-Teriflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
• Brand: TRC
• Description: Impurity Leflunomide USP Related Compound BApplications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)

Chemical properties

• Molecular weight: 270.21
• Formula: C₁₂H₉F₃N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)
• SMILES: C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1