2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

CAS: 145100-51-2

Ref. TR-B585565

Product Information

• Name: 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
• Synonyms: N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide, Comins' Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridinamine, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, N-(5-Chloro-2-pyridyl)triflimide, N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide, NSC 683533
• Brand: TRC

Description

Stability Moisture Sensitive, Unstable in DMSO Solution
Applications 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine also known as Comins’ Reagent is used as a triflyl compouind in the synthesis of vinyl triflates from metallo enolates.
References Comins, D., et al.: Tetrahedron Lett., 33, 6299 (1992);

Chemical properties

• Molecular weight: 392.68
• Formula: C₇H₃ClF₆N₂O₄S₂
• Color/Form: Neat
• InChI: InChI=1S/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H
• InChI key: InChIKey=TUFGVZMNGTYAQD-UHFFFAOYSA-N
• SMILES: O=S(=O)(N(c1ccc(Cl)cn1)S(=O)(=O)C(F)(F)F)C(F)(F)F