CAS 145100-51-2

N-(5-chloro-2-pyridyl)bis(trifluoro-methanesulfonimide)

Description:

N-(5-chloro-2-pyridyl)bis(trifluoromethanesulfonimide), with the CAS number 145100-51-2, is a chemical compound characterized by its unique structure, which includes a pyridine ring substituted with a chlorine atom and two trifluoromethanesulfonimide groups. This compound is typically a solid at room temperature and is known for its high thermal stability and solubility in polar organic solvents. The presence of trifluoromethanesulfonimide groups imparts strong acidity and makes it a potent electrophile, which can be utilized in various chemical reactions, including nucleophilic substitutions and as a reagent in organic synthesis. Additionally, the chlorine substituent on the pyridine ring can influence the compound's reactivity and interaction with other chemical species. Due to its properties, this compound may find applications in pharmaceuticals, agrochemicals, and materials science, particularly in the development of ionic liquids and as a catalyst in organic transformations. Safety precautions should be observed when handling this compound, as it may pose health hazards.

Formula: C₇H₃ClF₆N₂O₄S₂

InChI: InChI=1S/C7H3ClF6N2O4S2/c8-4-1-2-5(15-3-4)16(21(17,18)6(9,10)11)22(19,20)7(12,13)14/h1-3H

InChI key: InChIKey=TUFGVZMNGTYAQD-UHFFFAOYSA-N

SMILES: N(S(C(F)(F)F)(=O)=O)(S(C(F)(F)F)(=O)=O)C1=CC=C(Cl)C=N1

Synonyms:

• 1-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
• 2-[N,N-Bis(Trifluoromethanesulfonyl)Amino]-5-Chloropyridine
• 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine
• 2-[N,N-Bis(trifluoromethanesulphonyl)amino]-5-chloropyridine
• 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
• Bistrifluoromethylsulfonylaminochloropyridine
• Comins
• Comins' reagent
• Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
• N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridinamine
• N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine
• N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
• N-(5-Chloro-2-pyridyl)-N-(trifluoromethanesulfonyl)trifluoromethanesulfonamide
• N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
• N-(5-Chloro-2-pyridyl)triflimide
• N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
• NSC 683533
• N-(5-CHLORO-2-PYRIDYL)BIS(TRILFUOROMETHANESULFONIMIDE)
• 2-[N,N-bis(trifluoromethylsulphony)amino]-5-chloropyridine
• n-(5-chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
• 2-N,N-Bis(trifluoromethanesulfonyl)aminoü-5-chloropyridine, 99%
• N-(5-chloro-2-pyridyl)bis(trifluromethanesulfonimide
• 2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]
• Comins Reagent, N,N-Bis(trifluoromethylsulfonyl)-5-chloro-2-pyridylamine, 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine [Triflating Reagent]

CAS: 145100-51-2

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: >96.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 392.67

Ref: 3B-B1865

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine, 99%

CAS: 145100-51-2

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine provides good yields of vinyl triflates from the corresponding ketone enolates or dienolates. It is used in the total synthesis of (-)-porantheridine and the trans decahydroquinoline alkaloid (+)-219A. It is also used as a reactant for Suzuk

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: 99%

Color and Shape: White to pale yellow or cream, Crystalline powder

Molecular weight: 392.67

Ref: 02-L16929

Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-

CAS: 145100-51-2

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 392.6831

Ref: IN-DA001KJZ

2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine

CAS: 145100-51-2

2-{Bis[(trifluoromethyl)sulphonyl]amino}-5-chloropyridine

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: ≥95%

Color and Shape: Off-white Solid

Molecular weight: 392.68313

Ref: 54-PC3128

N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)

CAS: 145100-51-2

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: ≥ 98.0%

Color and Shape: White to orange or brown powder or solid

Molecular weight: 392.68

Ref: 7W-GX3787

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

CAS: 145100-51-2

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: 95%

Color and Shape: Solid, Chunks or Crystalline Powder

Molecular weight: 392.67

Ref: 10-F009051

Comin's reagent

CAS: 145100-51-2

Comin's reagent is a sulfonation agent that reacts with an enolate and forms a sulfonic acid. The reaction can be used to synthesize chiral compounds. Comin's reagent is selective for the (R) configuration of acetylcholine and can be used to synthesize α-amino acids from chiral alcohols and esters. Comin's reagent is also used in the synthesis of neurotrophic or growth factor compounds, which are proteins that promote cell growth or differentiation. These functional groups are found in natural products such as nicotinic acetylcholine, thallusin, and growth factor.

Formula: C₇H₃ClF₆N₂O₄S₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 392.68 g/mol

Ref: 3D-FC10786

2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

Controlled Product

CAS: 145100-51-2

Stability Moisture Sensitive, Unstable in DMSO Solution
Applications 2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine also known as Comins’ Reagent is used as a triflyl compouind in the synthesis of vinyl triflates from metallo enolates.
References Comins, D., et al.: Tetrahedron Lett., 33, 6299 (1992);

Formula: C₇H₃ClF₆N₂O₄S₂

Color and Shape: Neat

Molecular weight: 392.68

Ref: TR-B585565