(S)-(-)-Carbidopa

CAS: 28860-95-9

Ref. TR-C175985

Product Information

• Name: (S)-(-)-Carbidopa
• Synonyms: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, (-)-<span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid, (-)-<span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate, (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid, (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate, (2S)-2-(Aminoazaniumyl)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate, (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, (S)-Carbidopa, (αS)-α-Hydrazinyl-3,4-dihydroxy-α-methylbenzenepropanoic acid, 1-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid, <span class="text-smallcaps">L</span>-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid, <span class="text-smallcaps">L</span>-Carbidopa, <span class="text-smallcaps">L</span>-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid, <span class="text-smallcaps">L</span>-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid, <span class="text-smallcaps">L</span>-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid, <span class="text-smallcaps">L</span>-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid, <span class="text-smallcaps">L</span>-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid, <span class="text-smallcaps">L</span>-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid, <span class="text-smallcaps">L</span>-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid, <span class="text-smallcaps">L</span>-α-Methyldopahydrazine, Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (S)-, Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-, Cabidopa, Carbidopa, HMD, Hydrazino-α-methyldopa, Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, <span class="text-smallcaps">L</span>-, Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, L-, L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid, L-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid, L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid, L-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid, L-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid, L-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid, L-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid, L-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid, L-α-Methyldopahydrazine, Lodosin, Lodosyn, Mk 486, N-Aminomethyldopa, α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid, α-Methyldopahydrazine, Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αS)-, L-alpha-Methyldopahydrazine, 3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid, Tocris-0455, 1-(Mesithylene-2-sulfonyl)-3-nitro-1,2,4-triazole, L-alpha-Methyl-alpha-hydrazino-beta-(3,4-dihydroxyphenylpropionic acid, Carbidopum [INN-Latin], alpha-Hydrazino-alpha-methyl-beta-(3,4-dihydroxyphenyl)propionic acid, CCRIS 5093, 3-(3,4-DIHYDROXY-PHENYL)-2-HYDRAZINO-2-METHYL-PROPIONIC ACID, (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (1:1), (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid, SMR000058235, NCGC00024596-01, (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-(S )-, Carbidopa anhydrous, Benzenepropanoic acid, alpha-Methyldopahydrazine, L-alpha-Methyl-beta-(3,4-dihydroxyphenyl)-alpha-hydrazinopropionic aci d, alpha-HYDRAZINO-3,4-DIHYDROXY-alpha-METHYL-L-KINSON, Hadrazino-alpha-methyldopa, MLS000069628, Carbidopa [USAN:BAN:INN:JAN]

Description

Stability Unstable in Solution
Applications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.
References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);

• Brand: TRC

Chemical properties

• Molecular weight: 226.23
• Formula: C₁₀H₁₄N₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• InChI key: InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N
• SMILES: C[C@@](Cc1ccc(O)c(O)c1)(NN)C(=O)O