(S)-(-)-Carbidopa

CAS: 28860-95-9

Ref. TR-C175985

Product Information

• Name: (S)-(-)-Carbidopa
• Synonyms: (αS)-α-Hydrazinyl-3,4-dihydroxy-α-methylbenzenepropanoic acid (ACI), Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (S)- (ZCI), Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αS)- (9CI), Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, L- (8CI), (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic acid, (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate, (2S)-2-(Aminoazaniumyl)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate, (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, 1-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid, L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid, L-Carbidopa, L-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic acid, L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid, L-α-Hydrazino-α-methyl-3,4-dihydroxyphenylpropionic acid, L-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid, L-α-Methyl-α-hydrazino-3,4-dihydroxyphenylpropionic acid, L-α-Methyl-α-hydrazino-β-(3,4-dihydroxyphenyl)propionic acid, L-α-Methyl-β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic acid, L-α-Methyldopahydrazine, Cabidopa, Carbidopa, HMD, Hydrazino-α-methyldopa, Lodosin, Lodosyn, MK 486, N-Aminomethyldopa, α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
• Brand: TRC
• Description: Stability Unstable in SolutionApplications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993)

Chemical properties

• Molecular weight: 226.23
• Formula: C₁₀H₁₄N₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
• InChI key: InChIKey=TZFNLOMSOLWIDK-JTQLQIEISA-N
• SMILES: C[C@@](Cc1ccc(O)c(O)c1)(NN)C(=O)O