(±)-Cetirizine-d4 Dihydrochloride

CAS: 1219803-84-5

Ref. TR-C281103

Product Information

• Name: (±)-Cetirizine-d4 Dihydrochloride
• Synonyms: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]-1,1,2,2-tetradeuterioethoxy]acetic acid;dihydrochloride

Description

Applications (±)-Cetirizine-d4 Dihydrochloride is the labeled analogue of Cetirizine Dihydrochloride (C281100), a nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.
References De Vos, C., et al.: Ann. Allergy, 59, 278 (1987); Juhlin, L., et al.: J. Allergy Clin. Immunol., 80, 599 (1987); Fadel, R., et al.: Clin. Allergy, 17, 373 (1987); Gengo, F.M., et al.: Clin. Pharmacol. Ther., 42, 265 (1987)

• Brand: TRC

Chemical properties

• Molecular weight: 465.83
• Formula: C₂₁H₄H₂₁ClN₂O₃ClH
• Color/Form: Neat
• InChI: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/i14D2,15D2
• InChI key: InChIKey=ZKLPARSLTMPFCP-QZPARXMSSA-N
• SMILES: [2H]C([2H])(OCC(=O)O)C([2H])([2H])N1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1