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2-Chloro-5-nitro-N-4-phenylbenzamide
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2-Chloro-5-nitro-N-4-phenylbenzamide

CAS: 22978-25-2

Ref. TR-C374050

10mg
123.00 €
25mg
275.00 €
Estimated delivery in United States, on Tuesday 21 Jan 2025

Product Information

Name:
2-Chloro-5-nitro-N-4-phenylbenzamide
Controlled Product
Synonyms:
  • 2-chloro-5-nitro-N-phenylbenzamide
  • 2-Chloro-5-nitrobenzanilide
  • Benzamide, 2-chloro-5-nitro-N-phenyl-
  • Benzanilide, 2-chloro-5-nitro-
  • Gw 9622
  • Gw 9662
  • Gw9662
  • 2-Chloro-5-nitro-N-phenylbenzamide
Description:

Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb
References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
276.68
Formula:
C13H9ClN2O3
Color/Form:
Off-White
InChI:
InChI=1S/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17)
SMILES:
O=C(Nc1ccccc1)c1cc([N+](=O)[O-])ccc1Cl
MDL:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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