Cytarabine

CAS: 147-94-4

Ref. TR-C998100

Product Information

• Name: Cytarabine
• Synonyms: 4-amino-1-beta-d-arabinofuranosylpyrimidin-2(1H)-one, (Arabinofuranosyl)cytosine, 1-(Arabinofuranosyl)cytosine, 1-(β-<span class="text-smallcaps">D</span>-Arabinofuranosyl)cytosine, 1-(β-D-Arabinofuranosyl)cytosine, 1-b-D-Arabinofuranosylcytosine, 1-β-<span class="text-smallcaps">D</span>-Arabinosylcytosine, 1-β-Arabinofuranosylcytosine, 1-β-D-Arabinosylcytosine, 2(1H)-Pyrimidinone, 4-amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-, 2(1H)-Pyrimidinone, 4-amino-1-β-D-arabinofuranosyl-, 4-Amino-1-Beta-D-Arabinofuranosyl-2(1H)-Pyrimidinone, 4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one, 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine, 4-Amino-1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2(1H)-pyrimidinone, 4-Amino-1-β-D-Arabinofuranosyl-2(1H)-pyrimidinone, 4-amino-1-(D-arabinofuranosyl)pyrimidin-2(1H)-one, 4-amino-1-(beta-D-arabinofuranosyl)pyrimidin-2(1H)-one, 4-amino-1-[(2R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one, 4-amino-1-pentofuranosylpyrimidin-2(1H)-one, Ac 1075, Alexan, Ara-C, Ara-cell, ArabinoFuranosylcytosine, Arabinocytidine, Arabinocytosine, Arabinoside C, Arabitin, Aracytidine, Aracytin, Aracytine, Arafcyt, Chx 3311, Citarabina, Citozar, Cyclocide, Cylocide, Cylocide N, Cytarabin, Cytarabinoside, Cytosar, Cytosar U, Cytosine Arabinoside, Cytosine β-<span class="text-smallcaps">D</span>-arabinofuranoside, Cytosine β-<span class="text-smallcaps">D</span>-arabinoside, Cytosine β-D-arabinofuranoside, Cytosine β-D-arabinoside, Cytosine, 1-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-, Cytosine, 1-β-D-arabinofuranosyl-, Cytosine-1-β-<span class="text-smallcaps">D</span>-arabinofuranoside, Cytosine-1-β-D-arabinofuranoside, Cytosine-1-β-arabinofuranoside, DepoCyt, DepoCyte, Erpalfa, Iretin, Mk 8242, N-(2-oxo-2,3-dihydropyrimidin-4-yl)-D-arabinofuranosylamine, Nsc 287459, Nsc 63878, Sch 900242, Spongocytidine, Tarabine PFS, U 19920, U 19920A, Udicil, ara-Cytosine

Description

Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.
References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);

• Brand: TRC

Chemical properties

• Molecular weight: 243.22
• Formula: C₉H₁₃N₃O₅
• Color/Form: Neat
• InChI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• InChI key: InChIKey=UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• SMILES: Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1