Dexrazoxane

CAS: 24584-09-6

Ref. TR-D299050

Product Information

• Name: Dexrazoxane
• Synonyms: 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-, 2,6-Piperazinedione, 4,4'-propylenedi-, (+)- (8CI), 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione], (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, ADR 529, ICRF 187, NSC 169780, Savene, Totect, Zinecard, 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion, 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione, Eucardion, 4,4′-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione], 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione, 2,6-Piperazinedione, 4,4′-(1-methyl-1,2-ethanediyl)bis-, (S)-, 2,6-Piperazinedione, 4,4′-propylenedi-, (+)-, (+)-4,4'-Propylenedi-2,6-piperazinedione, (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione, 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione), (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE, 2,6-Piperazinedione, 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-

Description

Applications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
References Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)

• Brand: TRC

Chemical properties

• Molecular weight: 268.27
• Formula: C₁₁H₁₆N₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChI key: InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N
• SMILES: C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1