CAS 24584-09-6
:Dexrazoxane
Description:
Dexrazoxane is a synthetic compound primarily used as a cardioprotective agent in cancer therapy, particularly to mitigate the cardiotoxic effects of anthracycline chemotherapy agents like doxorubicin. It functions as a topoisomerase II inhibitor and is also known for its ability to chelate iron, thereby reducing oxidative stress and free radical formation in cardiac tissues. Dexrazoxane is typically administered intravenously and is characterized by its relatively low solubility in water, which can influence its formulation and delivery. The compound has a molecular formula that reflects its complex structure, and it is classified as a member of the class of compounds known as benzamides. Its efficacy and safety profile have been evaluated in various clinical settings, leading to its approval for use in specific patient populations. While it is generally well-tolerated, potential side effects may include myelosuppression and gastrointestinal disturbances. Overall, dexrazoxane plays a crucial role in enhancing the therapeutic index of certain chemotherapeutic regimens by protecting the heart from damage.
Formula:C11H16N4O4
InChI:InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChI key:InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N
SMILES:C([C@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
Synonyms:- 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dion
- 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione
- (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
- Eucardion
- 4,4′-[(1S)-1-Methyl-1,2-ethanediyl]bis[2,6-piperazinedione]
- 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
- 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione
- 2,6-Piperazinedione, 4,4′-(1-methyl-1,2-ethanediyl)bis-, (S)-
- 2,6-Piperazinedione, 4,4′-propylenedi-, (+)-
- (+)-4,4'-Propylenedi-2,6-piperazinedione
- (+)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione
- 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione)
- (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE
- See more synonyms
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Dexrazoxane
CAS:Formula:C11H16N4O4Purity:>98.0%(T)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:268.27Dexrazoxane ((S)-Razoxane)
CAS:Formula:C11H16N4O4Color and Shape:White To Off-White SolidMolecular weight:268.27Dexrazoxane
CAS:Controlled ProductApplications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
References Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)Formula:C11H16N4O4Color and Shape:NeatMolecular weight:268.27Dexrazoxane
CAS:Dexrazoxane (ICRF-187) is a mitosis-blocking anticancer drug, iron chelator, and anthracycline cardioprotectant.Formula:C11H16N4O4Purity:99.82% - 99.88%Color and Shape:SolidMolecular weight:268.2691Dexrazoxane
CAS:Formula:C11H16N4O4Purity:≥ 98.0% (dried basis)Color and Shape:White to off-white, pale yellow or beige powder or crysalsMolecular weight:268.27Dexrazoxane - Bio-X ™
CAS:Dexrazoxane is a cytoprotective drug that is used in chemotherapy to provide cardio-protection against anthracycline toxicity. It is an antimitotic agent with immunosuppressive properties. Dexrazoxane works by binding to iron in the cell, preventing it from being released. Dexrazoxane is also a catalytic inhibitor of topoisomerase II.Formula:C11H16N4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:268.27 g/molDexrazoxane
CAS:Topoisomerase II inhibitor; iron chelatorFormula:C11H16N4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:268.27 g/mol(S)-4,4′-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
CAS:Formula:C11H16N4O4Purity:98% (HPLC)Color and Shape:SolidMolecular weight:268.273
