Product Information
Name:3,3'-Diindolylmethane
Controlled Product
Synonyms:
- 1H-Indole
- 3,3'-methylenebis-
- Indole
- 3,3'-methylenedi- (6CI,7CI,8CI)
- 3,3'-Methylenebis[1H-indole]
- 3,3'-Bisindolylmethane
- Arundine
- Bis(1H-indol-3-yl)methane
- Bis(3-indolyl)methane
- Cervicon-DIM
- DIM (AhR agonist)
- DIM (diindolylmethane)
- Diindolylmethane
- HB 236
- See more synonyms
Brand:TRC
Description:Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),
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Chemical properties
Molecular weight:246.31
Formula:C17H14N2
Color/Form:Neat
InChI:InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChI key:InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N
SMILES:c1ccc2c(Cc3c[nH]c4ccccc34)c[nH]c2c1
Technical inquiry about: 3,3'-Diindolylmethane
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