3,3'-Diindolylmethane

CAS: 1968-05-4

Ref. TR-D455190

Product Information

• Name: 3,3'-Diindolylmethane
• Synonyms: 1H-Indole, 3,3'-methylenebis-, Indole, 3,3'-methylenedi- (6CI,7CI,8CI), 3,3'-Methylenebis[1H-indole], 3,3'-Bisindolylmethane, Arundine, Bis(1H-indol-3-yl)methane, Bis(3-indolyl)methane, Cervicon-DIM, DIM (AhR agonist), DIM (diindolylmethane), Diindolylmethane, HB 236, Infemin, 1H-Indole, 3,3′-methylenebis-, 3,3'-Methylenebisindole, 3,3'-methanediylbis(1H-indole), 3,3'Diindolemethane, 3,3-Methylenediindole, 3,3′-Bisindolylmethane, 3,3′-Methanediyldi(1H-indole), 3,3′-Methylenebis[1H-indole], 3-[(1H-Indol-3-yl)methyl]-1H-indole, DIM, Di(1H-indol-3-yl)methane, Diindoylmethane, Hb 236, Indole, 3,3′-methylenedi-, 3,3-Diindolylmethane, 3,3′-Diindolylmethane

Description

Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),

• Brand: TRC

Chemical properties

• Molecular weight: 246.31
• Formula: C₁₇H₁₄N₂
• Color/Form: Neat
• InChI: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
• InChI key: InChIKey=VFTRKSBEFQDZKX-UHFFFAOYSA-N
• SMILES: c1ccc2c(Cc3c[nH]c4ccccc34)c[nH]c2c1