Product Information
- 1H-Indole
- 3,3'-methylenebis-
- Indole
- 3,3'-methylenedi- (6CI,7CI,8CI)
- 3,3'-Methylenebis[1H-indole]
- 3,3'-Bisindolylmethane
- Arundine
- Bis(1H-indol-3-yl)methane
- Bis(3-indolyl)methane
- Cervicon-DIM
- See more synonyms
- DIM (AhR agonist)
- DIM (diindolylmethane)
- Diindolylmethane
- HB 236
- Infemin
- 1H-Indole, 3,3′-methylenebis-
- 3,3'-Methylenebisindole
- 3,3'-methanediylbis(1H-indole)
- 3,3'Diindolemethane
- 3,3-Methylenediindole
- 3,3′-Bisindolylmethane
- 3,3′-Methanediyldi(1H-indole)
- 3,3′-Methylenebis[1H-indole]
- 3-[(1H-Indol-3-yl)methyl]-1H-indole
- DIM
- Di(1H-indol-3-yl)methane
- Diindoylmethane
- Hb 236
- Indole, 3,3′-methylenedi-
Applications 3,3'-Diindolylmethane is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. 3,3'-Diindolylmethane is an antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.
References Kandala, et al.: Mol.Pharmacol., 78, 297 (2010), Kandala, et al.: J. Pharmacol. Exp. Ther., 341 24 (2012),
Chemical properties
Technical inquiry about: TR-D455190 3,3'-Diindolylmethane
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