Epalrestat-d5

CAS: 82159-09-9

Ref. TR-E565302

Product Information

• Name: Epalrestat-d5
• Synonyms: (5Z)-5-[(2E)-2-Methyl-3-phenyl-d5-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid, Eabeth-d5, Kinedak-d5, ONO 2235-d5, Sorbistat-d5, (5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic acid, 2-[(Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl]acetic acid, 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-, 3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (Z,E)-, 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-, 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propenylidene]-4-oxo-2-thioxo-, (5Z)-, 5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid, 5-((Z,E)-beta-Methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid, Eabeth, Epalrestat [INN], Epalrestatum, Epalrestatum [Latin], Kinedak, Ono 2235, Sorbistat, Unii-424Dv0807X, {(5E)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid

Description

Applications Epalrestat-d5 is the labeled analogue of Epalrestat (E565300), an aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983); Kikkawa, R., et al.: Diabetologia, 24, 290 (1983); Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985)

• Brand: TRC

Chemical properties

• Molecular weight: 324.43
• Formula: C₁₅H₈D₅NO₃S₂
• Color/Form: Neat
• InChI: InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-/i2D,3D,4D,5D,6D
• InChI key: InChIKey=CHNUOJQWGUIOLD-CUEOMABLSA-N
• SMILES: [2H]c1c([2H])c([2H])c(/C=C(C)/C=C2\SC(=S)N(CC(=O)O)C2=O)c([2H])c1[2H]