Folinic Acid

CAS: 58-05-9

Ref. TR-F680340

Product Information

• Name: Folinic Acid
• Synonyms: 5-Formyl-5,6,7,8-tetrahydrofolic Acid, 5-Formyltetrahydrofolic Acid, 5-Formyltetrahydropteroylglutamic Acid, CF, Folinic acid-SF, Kunyrin, Leucal, Leucoverin, Leucovorin, N5-Formyl-5,6,7,8-tetrahydrofolic Acid, N5-Formyl-THF, N5-Formyltetrahydrofolic Acid, Welcovorin, l-Leucovorin
• Brand: TRC
• Description: Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)

Chemical properties

• Molecular weight: 473.45
• Formula: C₂₀H₂₃N₇O₇
• Color/Form: Neat
• InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
• InChI key: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N
• SMILES: Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2C=O