Gliotoxin
CAS:
Ref. TR-G410200
Product Information
Name:Gliotoxin
Synonyms:
- 10H-3,10a-Epidithiopyrazino[1,2-a]indole-1,4-dione
- 2,3,5a,6-tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-
- [3R-(3α,5aβ,6β,10aα)]- (8CI)
- Gliotoxin (6CI,7CI)
- (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
- Aspergillin
- S. N. 12870
Brand:TRC
Description:Applications Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Takahashi, M., et al.: J. Antibiotics., 65, 263 (2012); Li., Y.G., et al.: Biochem. Biophy. Rsch. Commun., 422, 85 (2012); Zhang, H.C., et al.: Applied, Mech. Mater., 178, 783 (2012); Scharf, D.H., et al.: Appl. Microbiol. Biotechnol., 93, 467 (2012);
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Chemical properties
Molecular weight:326.39
Formula:C13H14N2O4S2
Color/Form:Neat
InChI:InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChI key:InChIKey=FIVPIPIDMRVLAY-RBJBARPLSA-N
SMILES:CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3