Product Information
Name:(-)-Huperzine A-d7 major (>90%)
Controlled Product
Synonyms:
- (5R,9R,11E)-5-Amino-11-(ethylidene-2,2,2-d3)-5,6,9,10-tetrahydro-7-(methyl-d3-)-5,9-methanocycloocta[b]pyridin-2(1H)-one-d7
Brand:TRC
Description:
Applications (-)-Huperzine A-d7 major (>90%) is the labelled form of (-)-Huperzine A (H826000), a reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.
References Wang, Y.-E., et al.: Acta Pharmacol. Sin., 7, 110 (1986), Ved, H.S., et al.: Neuroreport, 8, 963 (1997)
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Chemical properties
Molecular weight:249.359
Formula:C15D7H11N2O
Purity:>90%
Color/Form:Neat
InChI:InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1/i2D3,5D,6D,7D2
InChI key:InChIKey=ZRJBHWIHUMBLCN-UWCUZVGFSA-N
SMILES:[2H]C1=C(C([2H])([2H])[2H])C[C@@]2(N)/C(=C/C)[C@@H]1C([2H])([2H])c1[nH]c(=O)c([2H])cc12
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