Estimated delivery in United States, on Tuesday 28 May 2024
Product Information
Name:
IMD 0354
Synonyms:
- 5-Chloro-α,α,α,α',α',α'-hexafluoro-3',5'-salicyloxylidide N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
- Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-
- Tcmdc-125465
CAS:
Description:
Applications IMD 0354 is an inhibitor of IKK β (IKK-2) and blocks Iκβα phosphorylation in the NF-κB pathway. IMD 0354 might also have therapeutic efficacy in the treatment of human mesothelioma.
References Nishikawa, S., et al.: Cancer Med., 3, 416 (2014); Tanka., A., et al.: Blood, 105, 2324 (2005); Sugita. A., et al.: Int. Arch. Allergy Immunol, 148, 186 (2009); Kamon, J.M., et al.:Biochem., Biophys, Res. Commun,, 323, 242 (2004); Onai, et al.: Cardiovasc. Res., 63, 51 (2004)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
383.67
Formula:
C15H8ClF6NO2
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C26H42O6/c1-17-15-18-19(21(2)9-10-24(16-25(17,21)27)31-13-14-32-24)5-7-22(3)20(18)6-8-26(22,28)23(4)29-11-12-30-23/h17-20,27-28H,5-16H2,1-4H3/t17-,18-,19-,20-,21-,22+,25-,26+/m1/s1
InChI key:
InChIKey=WOEHXCDLEYXISO-NMRJUBPYSA-N
SMILES:
C[C@@H]1C[C@H]2[C@H]3CC[C@@](O)(C4(C)OCCO4)[C@@]3(C)CC[C@H]2[C@@]2(C)CCC3(C[C@@]12O)OCCO3
MDL:
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EINECS:
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HS code:
Technical inquiry about: TR-I268650 IMD 0354
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