CAS 978-62-1

N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

Description:

N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide, with CAS number 978-62-1, is a chemical compound characterized by its complex structure, which includes a benzamide core substituted with both a chloro group and a hydroxy group, as well as a phenyl ring that carries two trifluoromethyl groups. This compound exhibits notable hydrophobicity due to the presence of the trifluoromethyl groups, which can influence its solubility and interaction with biological systems. The chloro and hydroxy substituents contribute to its potential reactivity and ability to form hydrogen bonds, which may enhance its biological activity. The presence of multiple electronegative fluorine atoms can also affect the compound's electronic properties, making it of interest in medicinal chemistry and material science. Its unique characteristics may render it useful in various applications, including pharmaceuticals, agrochemicals, and as a research tool in studying biological pathways. However, specific safety and handling guidelines should be followed due to its chemical nature.

Formula: C₁₅H₈ClF₆NO₂

InChI: InChI=1/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChI key: CHILCFMQWMQVAL-UHFFFAOYSA-N

SMILES: c1cc(c(cc1Cl)C(=Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)O)O

Synonyms:

• Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-
• Tcmdc-125465
• N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
• N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

IMD-0354

CAS: 978-62-1

Formula: C₁₅H₈ClF₆NO₂

Purity: ≥ 95.0%

Color and Shape: White to off-white solid

Molecular weight: 383.67

Ref: 7W-GL0778

N-(3,5-Bistrifluoromethylphenyl)-5-Chloro-2-Hydroxybenzamide

CAS: 978-62-1

N-(3,5-Bistrifluoromethylphenyl)-5-Chloro-2-Hydroxybenzamide

Formula: C₁₅H₈ClF₆NO₂

Purity: 98%

Molecular weight: 383.67

Ref: 54-PC108696

IMD-0354

CAS: 978-62-1

IMD-0354

Formula: C₁₅H₈ClF₆NO₂

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 383.67

Ref: 54-BUP09917

N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

CAS: 978-62-1

Formula: C₁₅H₈ClF₆NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.6729

Ref: IN-DA0036S1

IMD-0354

CAS: 978-62-1

IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.

Formula: C₁₅H₈ClF₆NO₂

Purity: 99.65% - 99.98%

Color and Shape: Solid

Molecular weight: 383.67

Ref: TM-T6141

IMD-0354

CAS: 978-62-1

N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide

Formula: C₁₅H₈ClF₆NO₂

Purity: 98%

Molecular weight: 383.67

Ref: IN-DG306084

IMD-0354

CAS: 978-62-1

Purity: 98%

Molecular weight: 383.015

Ref: 10-F862429

IMD 0354

Controlled Product

CAS: 978-62-1

Applications IMD 0354 is an inhibitor of IKK β (IKK-2) and blocks Iκβα phosphorylation in the NF-κB pathway. IMD 0354 might also have therapeutic efficacy in the treatment of human mesothelioma.
References Nishikawa, S., et al.: Cancer Med., 3, 416 (2014); Tanka., A., et al.: Blood, 105, 2324 (2005); Sugita. A., et al.: Int. Arch. Allergy Immunol, 148, 186 (2009); Kamon, J.M., et al.:Biochem., Biophys, Res. Commun,, 323, 242 (2004); Onai, et al.: Cardiovasc. Res., 63, 51 (2004)

Formula: C₁₅H₈ClF₆NO₂

Color and Shape: Neat

Molecular weight: 383.67

Ref: TR-I268650