Ivermectin B1a-D2

CAS: 71827-03-7

Ref. TR-I940817

Product Information

• Name: Ivermectin B1a-D2
• Synonyms: 5-O-Demethyl-22,23-dihydro-avermectin A1a-D2, 2,23-Dihydroavermectin B1a-D2, Dihydroavermectin B1a-D2, (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside, 22,23-Dihydro-5-O-demethylavermectin A1a, 22,23-Dihydroavermectin B(1)a, 22,23-Dihydroavermectin B1a, 22,23-Dihydroavermectin B_1a, 5-O-Demethyl-22,23-dihydroavermectin A_1a, Avermectin A1a, 22,23-dihydro-5-O-demethyl-, Avermectin A_1a, 5-O-demethyl-22,23-dihydro-, Brn 4643153, Dihydroavermectin B1a, Dihydroavermectin B_1a, Ivermectin B1a, Ivermectin B_1a, Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv., Unii-91Y2202Ouw, Avermectin A1a, 5-O-demethyl-22,23-dihydro-, 5-O-Demethyl-22,23-dihydroavermectin A1a, Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A1a deriv.

Description

Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

• Brand: TRC

Chemical properties

• Molecular weight: 877.11
• Formula: C₄₈H₇₂D₂O₁₄
• Color/Form: Neat
• InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1/i17D,18D/t17?,18?,25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+
• InChI key: InChIKey=AZSNMRSAGSSBNP-GKMLSAQUSA-N
• SMILES: [2H]C1C([2H])[C@]2(C[C@@H]3C[C@@H](C/C=C(\C)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C4\CO[C@@H]5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@H]([C@@H](C)CC)[C@H]1C