Leflunomide

CAS: 75706-12-6

Ref. TR-L322750

Product Information

• Name: Leflunomide
• Synonyms: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, Arava, HWA 486, Leflunomida, Leflunomidum, SU 101, 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-, 5-Methylisoxazole-4-Carboxylic Acid (4-Trifluoromethyl)Anilide, 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazole carboxamide, Alpha,Alpha,Alpha-Trifluoro-5-Methyl-4-Isoxazolecarboxy-P-Toluidide, Avara, Cleft, Hwa 486, Hwa486, Lefumide, N-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide, Repso, Rs-34821, SU 101 (pharmaceutical), Su 101, alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine

Description

Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

• Brand: TRC

Chemical properties

• Molecular weight: 270.21
• Formula: C₁₂H₉F₃N₂O₂
• Color/Form: White To Off-White
• InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
• InChI key: InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
• SMILES: Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1