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2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione

CAS: 1009307-40-7 52096-60-3

Ref. TR-M332347

Estimated delivery in United States, on Wednesday 16 Dec 2020

Product Information

Name:
2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione
Description:

Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors.
References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228

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Chemical properties

Molecular weight:
228.32
Formula:
C11H4D7NO2S
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Hazard Info

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