CAS 1009307-40-7

Formula: C11H11NO2S

InChI: InChI=1S/C11H11NO2S/c1-15-7-6-12-10(13)8-4-2-3-5-9(8)11(12)14/h2-5H,6-7H2,1H3/i1D3,6D2,7D2

InChI key: OHKAYWGJHFQHSW-DDROHRSCSA-N

SMILES: [2H]C([2H])([2H])SC([2H])([2H])C([2H])([2H])N1C(=O)C2=CC=CC=C2C1=O

2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione

Controlled Product

CAS: 1009307-40-7

Applications 2-[2-(Methyl-d3-thio)ethyl-1,1,2,2-d4]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of Lapatinib-d7 Dihydrochloride (L175807), which is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic;Also, it is used in the preparation of 4-Aminoquinazolines as EGFR and HER-2 inhibitors.
References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005); Tung, R.: PCT Int. Appl. (2008), WO 2008024439 A2 20080228

Formula: C₁₁D₇H₄NO₂S

Color and Shape: Neat

Molecular weight: 228.319

Ref: TR-M332347