MK 1775

CAS: 955365-80-7

Ref. TR-M424975

Product Information

• Name: MK 1775
• Synonyms: Adavosertib, 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one, 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, 2-Allyl-1,8-Dimethoxy-9,10-Anthraquinone, 2-Allyl-1,8-Dimethoxyanthracene-9,10-Dione, 2-allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-, 9,10-Anthracenedione,1,8-dimethoxy-2-(2-propenyl), Azd 1775, Azd1775, Mk-1775, Wee 1-1

Description

Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.
References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);

• Brand: TRC

Chemical properties

• Molecular weight: 500.6
• Formula: C₂₇H₃₂N₈O₂
• Color/Form: Light Yellow
• InChI: InChI=1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
• InChI key: InChIKey=NASXCEITKQITLD-UHFFFAOYSA-N
• SMILES: O=C1c2ccccc2C(=O)C1c1ccc(F)cc1