Product Information
Name:Monastrol
Controlled Product
Synonyms:
- ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Brand:TRC
Description:Applications Monastrol is a small molecule that inhibits mitotic kinesin Eg5 and arrests cells in mitosis with monopolar spindles (1, 2).Monastrol is an anticancer agent against MCF-7 tumor cells (3).References (1) Mayer, T.U., et al.: Science (1999) 286, 971 (2) Kappe, C.O., et al.: Tetrahedron (2000) 56, 1859 Marques, L.A., et al.: Naunyn-Schmiedeberg’s Arch Pharmacol (2016) [Epub ahead of print]
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:292.35
Formula:C14H16N2O3S
Color/Form:Neat
InChI:InChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChI key:InChIKey=LOBCDGHHHHGHFA-UHFFFAOYSA-N
SMILES:CCOC(=O)C1=C(C)NC(=S)NC1c1cccc(O)c1
Technical inquiry about: Monastrol
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