Nicergoline

CAS: 27848-84-6

Ref. TR-N394550

Product Information

• Name: Nicergoline
• Synonyms: Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8beta)-, Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- (9CI), Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI), Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv., Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8beta-yl)methyl ester (8CI), 1,6-Dimethyl-8beta-(5-bromonicotinoyloxymethyl)-10alpha-methoxyergoline, Cergodum, Circo-Maren, Dilasenil, Duracebrol, Ergobel, Ergotop, FI 6714, MNE, Memoq, NSC 150531, Nicergolent, Nicotergoline, Sermion, TA 079, Vasospan, (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate, (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate, (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester, 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline, 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether, 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat), 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German], 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester), 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate, 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester), 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline, Brn 4828393, Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester), Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester), Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-, Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-, Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-, Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI), Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester), Fi 6714, Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv., Nicergolin, Nicergolin [German], Nicergolina, Nicergolina [DCIT], Nicergoline [USAN:INN:BAN:JAN], Nicergolinum, Nicergolinum [INN-Latin], Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester, Nimergoline, Nimergoline base, Nsc 150531, Rp 19651, Ta 079, Unii-Jcv8365Fwn, [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate, [(8Beta)-10-Methoxy-1,6-Dimethylergolin-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
• CAS: 27848-84-6

Description

Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 484.39
• Formula: C₂₄H₂₆BrN₃O₃
• Color/Form: Neat
• InChI: InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
• InChI key: InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
• SMILES: CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13