CAS 27848-84-6

Nicergoline

Description:

Nicergoline is a synthetic compound classified as an ergoline derivative, primarily used for its neuroprotective and cognitive-enhancing properties. It is known for its ability to improve cerebral blood flow and enhance oxygen utilization in the brain, making it beneficial in treating cognitive disorders associated with aging and vascular issues. Nicergoline exhibits a complex structure, featuring a bicyclic ring system characteristic of ergolines, and it is typically administered in the form of its mesylate salt. The substance is soluble in water and exhibits moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. Its pharmacological effects are attributed to its action as an alpha-adrenergic antagonist and a serotonin receptor modulator, which contribute to its vasodilatory effects. Nicergoline is generally well-tolerated, with a side effect profile that may include dizziness, gastrointestinal disturbances, and headache. Due to its cognitive-enhancing properties, it has been explored in various clinical settings, particularly in the management of dementia and other cognitive impairments.

Formula:C₂₄H₂₆BrN₃O₃

InChI:InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key:InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N

SMILES:O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3

Synonyms:

(+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
(10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
(8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
Brn 4828393
Cergodum
Circo-Maren
Dilasenil
Duracebrol
Ergobel
Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
Ergotop
Fi 6714
Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
MNE
Memoq
Nicergolent
Nicergolin
Nicergolin [German]
Nicergolina
Nicergolina [DCIT]
Nicergoline [USAN:INN:BAN:JAN]
Nicergolinum
Nicergolinum [INN-Latin]
Nicotergoline
Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
Nimergoline
Nimergoline base
Nsc 150531
Rp 19651
Sermion
Ta 079
Unii-Jcv8365Fwn
Vasospan
[(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
See more synonyms

Purity (%)

100

products per page.Found 21 products.

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Nicergoline
CAS:
- 27848-84-6
Formula:C₂₄H₂₆BrN₃O₃
Purity:>98.0%(T)(HPLC)
Color and Shape:White to Light yellow powder to crystal
Molecular weight:484.39
Ref: 3B-N0904
100mg
40.00€
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1g
208.00€
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Nicergoline
CAS:
- 27848-84-6
Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic 1-adrenoceptors on vascular smooth muscle. This Thermo Scientific Chemicals brand product was originally part
Formula:C₂₄H₂₇BrN₃O₃
Color and Shape:White to yellow, Powder or granular powder
Molecular weight:485.40
Ref: 02-J63295
1g
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100mg
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Nicergoline
CAS:
- 27848-84-6
Color and Shape:Neat
Ref: 61-FOR0115.00
10mg
298.00€
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NICERGOLINE FOR PEAK IDENTIFICATION CRS
CAS:
- 27848-84-6
NICERGOLINE FOR PEAK IDENTIFICATION CRS
Formula:C₂₄H₂₆BrN₃O₃
Color and Shape:Powder
Molecular weight:484.3855
Ref: 41-Y0001362
1mg
132.00€
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NICERGOLINE CRS
CAS:
- 27848-84-6
NICERGOLINE CRS
Formula:C₂₄H₂₆BrN₃O₃
Color and Shape:Powder
Molecular weight:484.3855
Ref: 41-Y0001373
50mg
132.00€
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NICERGOLINE FOR SYSTEM SUITABILITY CRS
CAS:
- 27848-84-6
NICERGOLINE FOR SYSTEM SUITABILITY CRS
Formula:C₂₄H₂₆BrN₃O₃
Color and Shape:Powder
Molecular weight:484.3855
Ref: 41-Y0001352
10mg
132.00€
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Nicergoline
CAS:
- 27848-84-6
Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.
Formula:C₂₄H₂₆BrN₃O₃
Purity:98% - 99.80%
Color and Shape:White Solid
Molecular weight:484.39
Ref: TM-T1132
1mL*10mM (DMSO)
34.00€
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25mg
49.00€
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50mg
56.00€
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100mg
66.00€
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500mg
144.00€
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Nicergoline
CAS:
- 27848-84-6
Nicergoline
Formula:C₂₄H₂₆BrN₃O₃
Purity:98%
Molecular weight:484.39
Ref: 54-OR1029117
100mg
32.00€
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250mg
56.00€
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1g
140.00€
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5g
590.00€
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25g
2,621.00€
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Nicergoline
CAS:
- 27848-84-6
Formula:C₂₄H₂₆BrN₃O₃
Purity:98.5 - 102.0 % (anhydrous basis)
Color and Shape:White to off-white or light-yellow powder
Molecular weight:484.39
Ref: 7W-GP2573
ne
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Nicergoline-N1-13C-d3
CAS:
- 27848-84-6
Formula:C₂₃₁₃CH₂₃D₃BrN₃O₃
Molecular weight:488.40
Ref: 4Z-N-070016
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25mg
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100mg
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Nicergoline
CAS:
- 27848-84-6
Nicergoline
Formula:C₂₄H₂₆BrN₃O₃
Purity:≥98%
Molecular weight:484.39
Ref: 54-BUP17151
25mg
68.00€
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50mg
82.00€
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100mg
98.00€
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500mg
213.00€
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Nicergoline-13C-d3
CAS:
- 27848-84-6
Formula:C₂₃₁₃CH₂₃D₃BrN₃O₃
Color and Shape:White To Off-White Solid
Molecular weight:488.40
Ref: 4Z-N-070001
5mg
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100mg
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10mg
1,429.00€
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25mg
2,620.00€
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50mg
4,108.00€
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Nicergoline
CAS:
- 27848-84-6
Formula:C₂₄H₂₆BrN₃O₃
Color and Shape:White To Off-White Solid
Molecular weight:484.39
Ref: 4Z-N-070010
5mg
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100mg
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10mg
343.00€
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25mg
436.00€
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50mg
623.00€
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Nicergoline
CAS:
- 27848-84-6
Color and Shape:Neat
Ref: 86-MM0115.00
250mg
1,901.00€
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Nicergoline
CAS:
- 27848-84-6
Formula:C₂₄H₂₆BrN₃O₃
Molecular weight:484.4
Ref: ST-EA-CP-N40000
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Nicergoline-d3
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 27848-84-6
Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)
Formula:C₂₄D₃H₂₃BrN₃O₃
Color and Shape:Neat
Molecular weight:487.404
Ref: TR-N394552
1mg
343.00€
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10mg
2,285.00€
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Nicergoline
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 27848-84-6
Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)
Formula:C₂₄H₂₆BrN₃O₃
Color and Shape:Neat
Molecular weight:484.39
Ref: TR-N394550
50mg
98.00€
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100mg
129.00€
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1g
358.00€
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Nicergoline
CAS:
- 27848-84-6
Î±1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant
Formula:C₂₄H₂₆BrN₃O₃
Purity:Min. 95%
Color and Shape:White Powder
Molecular weight:484.4 g/mol
Ref: 3D-FB01518
500mg
205.00€
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1g
327.00€
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2g
479.00€
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5g
907.00€
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10g
1,465.00€
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Nicergoline - Bio-X ™
CAS:
- 27848-84-6
Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms associated with cerebrovascular abnormalities. This drug works by inhibiting alpha-1 adrenoreceptors on vascular smooth muscles which results in peripheral vasodilation. Furthermore, this drug has been suggested to ameliorate cognitive deficits.
Formula:C₂₄H₂₆BrN₃O₃
Purity:Min. 95%
Color and Shape:Powder
Molecular weight:484.39 g/mol
Ref: 3D-BN166697
10mg
186.00€
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Nicergoline N-Dimer
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 27848-84-6
Formula:C₄₇H₄₈Br₂N₆O₆
Color and Shape:Neat
Molecular weight:952.73
Ref: TR-N394560
25mg
10,511.00€
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