Estimated delivery in United States, on Monday 16 Dec 2024
Product Information
Name:
PCI-24781
Synonyms:
- CRA 024781
- CRA 24781
- 2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-
- 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
- Abexinostat
- Brd K12867552
- Cra 024781
- Cra 24781
- Pci 24781
- Thm-I 94
- See more synonyms
Description:
Applications PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
References Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000), Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2005), Esteller, M., et al.: Carcinogenesis, 27, 1121 (2006),
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
397.4244
Formula:
C21H23N3O5
Color/Form:
Neat
InChI:
InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
InChI key:
InChIKey=DQUXPVVSVXIQNE-ZOWNYOTGSA-N
SMILES:
CC[C@@]1(c2ccc(N)cc2)CCC(=O)NC1=O.O=C(O)C(O)C(O)C(=O)O
MDL:
Melting point:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-P216400 PCI-24781
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