PCI-34051

CAS: 950762-95-5

Ref. TR-P216600

Product Information

• Name: PCI-34051
• Synonyms: N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide

Description

Applications PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
References Balasubramanian, S. et al.: Leukemia, 22, 1026 (2008); Pipalia, N.H. et al.: Proc. Nat. Acad. Sci. USA, 108, 5620 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 296.32
• Formula: C₁₇H₁₆N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
• InChI key: InChIKey=AJRGHIGYPXNABY-UHFFFAOYSA-N
• SMILES: COc1ccc(Cn2ccc3ccc(C(=O)NO)cc32)cc1