Polymyxin B Sulfate

CAS: 1405-20-5

Ref. TR-P689400

Product Information

• Name: Polymyxin B Sulfate
• Synonyms: N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide Sulfuric Acid, Aerosporin, Mastimyxin, N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid, N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt), Polymixin B Sulfate, Polymyxin B (PMB), Polymyxin B 2,5-SULFATE, Polymyxin B Sulphate, Polymyxin B sulfate salt, Polymyxin B, Sulfat (Salz), Polymyxin B₁-polymyxin B₂ sulfate, polimixina B, sulfato (sal), polymyxin B sulfate, polymyxine B, sulfate (sel)

Description

Applications Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixture of Polymyxin B1 and B2 sulfate.
References Coppi, G., et al.: J. Pharm. Pharmacol., 60, 21 (2008), Roche, S., et al.: Food Microbiol., 26, 21 (2008), Kawanishi, T., et al.: Plant Pathol., 58, 237 (2009),

• Brand: TRC

Chemical properties

• Molecular weight: 1385.61
• Formula: C₅₅H₉₆N₁₆O₁₃H₂SO₄
• Color/Form: Colourless Crystalline
• InChI: InChi=1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)