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CAS 1405-20-5

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polymyxin B

Description:
Polymyxin B is a cyclic polypeptide antibiotic primarily used to treat infections caused by Gram-negative bacteria. It is derived from the bacterium Bacillus polymyxa and exhibits a unique structure characterized by a hydrophobic tail and a positively charged peptide ring, which allows it to disrupt bacterial cell membranes. This disruption leads to increased permeability and ultimately cell lysis, making it effective against a range of pathogens, including Pseudomonas aeruginosa and Escherichia coli. Polymyxin B is often used in topical formulations due to its nephrotoxicity and neurotoxicity when administered systemically. It is commonly found in ointments, eye drops, and other topical preparations. Additionally, polymyxin B has gained attention in the context of antibiotic resistance, as it is sometimes used as a last-resort treatment for multidrug-resistant infections. Its use, however, is limited by potential side effects and the emergence of resistant bacterial strains, necessitating careful consideration in clinical applications.
Formula:C56H100N16O17S
InChI:InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
SMILES:CC(C)CC1C(=NC(CCN)C(=NC(CCN)C(=NC(CCO)C(=NCCC(C(=NC(CCN)C(=NC(Cc2ccccc2)C(=N1)O)O)O)N=C(C(CCN)N=C(C(CCO)N=C(C(CCN)N=CO)O)O)O)O)O)O)O.OS(=O)(=O)O
Synonyms:
  • Aerosporin
  • Mastimyxin
  • N-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide,sulfuric acid
  • N~2~-[4-amino-2-(formylamino)butanoyl]-N-(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)homoserinamide sulfate (salt)
  • Polymixin B Sulfate
  • Polymyxin B (PMB)
  • Polymyxin B 2,5-SULFATE
  • Polymyxin B Sulphate
  • Polymyxin B sulfate salt
  • Polymyxin B, Sulfat (Salz)
  • See more synonyms
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