β-Pseudouridine

CAS: 1445-07-4

Ref. TR-P839605

Product Information

• Name: β-Pseudouridine
• Synonyms: 5-ß-D-Ribofuranosyl-2,4(1H,3H)-Pyrimidinedione, 5-(ß-D-Ribofuranosyl)uracil, 5-Ribosyluracil, NSC 162405, Pseudouridine C, ß-D-Pseudouridine, Pseudouridine, ?-Uridine, (1S)-1,4-anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, 1: PN: WO2017201317 SEQID: 1 claimed DNA, 2,4(1H,3H)-Pyrimidinedione, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, 5-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)uracil, 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione, 5-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione, 5-β-D-ribofuranosyluracil, B-Pseudouridine, Uracil, 5-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, β-<span class="text-smallcaps">D</span>-Pseudouridine, ψ-Uridine, Uracil, 5-β-D-ribofuranosyl-, 2,4(1H,3H)-Pyrimidinedione, 5-β-D-ribofuranosyl-

Description

Applications An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
References Ferré-D'Amaré A.R. et al.: Curr. Opin. Struct. Biol., 13, 49 (2003); Hamma, T. et al.: Chem. Biol., 13, 1125 (2006); Liang, X.H. et al.: RNA, 8, 237 (2002); Monobe, M. et al.: Mut. Res. Gen. Toxicol. Env. Mutagen., 538, 93 (2003);

• Brand: TRC

Chemical properties

• Molecular weight: 244.20
• Formula: C₉H₁₂N₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
• InChI key: InChIKey=PTJWIQPHWPFNBW-GBNDHIKLSA-N
• SMILES: O=c1[nH]cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1