Romidepsin-d8

CAS: 128517-07-7

Ref. TR-R425062

Product Information

• Name: Romidepsin-d8
• Synonyms: (1R,4S,7Z,10R,16E)-4-deuterio-7-ethylidene-4-(1,1,1,2,3,3,3-heptadeuteriopropan-2-yl)-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone, Fr 901228, Romidepsin, (1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone

Description

Applications Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),

• Brand: TRC

Chemical properties

• Molecular weight: 548.745
• Formula: C₂₄D₈H₂₈N₄O₆S₂
• Color/Form: Neat
• InChI: InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19?,20-/m0/s1/i4D3,5D3,14D,20D
• InChI key: InChIKey=OHRURASPPZQGQM-JYUKDPTESA-N
• SMILES: [2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])[C@]1([2H])NC(=O)/C(=C/C)NC(=O)[C@@H]2CSSCC/C=C/[C@@H](CC(=O)NC(C(C)C)C(=O)N2)OC1=O