Product Information
Name:SB 202190
Controlled Product
Synonyms:
- 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Brand:TRC
Description:Applications SB 202190 is a DFG inhibitor used in the treatment of colorectal cancer. It is a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.References Grossi, V. et al.: Canc. Biol. Ther., 13, 1471 (2012); Chen, Y. et al.: Med. Sci. Mon., 18, BR383 (2012); Horstmann, S. et al.: J. Neurosci. Res., 52, 483 (1998); Zhang, F. et al.: Zhong. Yao. Tong., 18, 512 (2002); Wang, J. et al.: Nanj. Yike Dax. Xue., 29, 840 (2009);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:331.34
Formula:C20H14FN3O
Color/Form:Off-White
InChI:InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChI key:InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N
SMILES:Oc1ccc(-c2nc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1
Technical inquiry about: SB 202190
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