Product Information
Name:SGI-1027
Controlled Product
Synonyms:
- N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-benzamide
Brand:TRC
Description:Applications SGI-1027 is a quinoline derivative and a potent inhibitor of DNA methyltransferase (DNMT). SGI-1027 can be used as a potential therapeutic agent for the treatment of cancer and other diseases and also as a research tool to investigate the role of DNMTs in epigenetic events.References Rilova, E., et al.: Chem. Med. Chem., 9, 590 (2014); Yoo, J., et al.: PLoS One, 8, e62152 (2013); Medina-Franco, J.L., et al.: Mol. Divers., 17, 337 (2013); Yoo, J., et al.: Curr. Comput-aid. Drug, 8, 317 (2012)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:461.518
Formula:C27H23N7O
Color/Form:Neat
InChI:InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
InChI key:InChIKey=NEGGNAWLXHJUEM-ZXNJLVRISA-N
SMILES:CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@@H]([C@@H](OC(=O)c3ccccc3)[C@]3(O)C[C@@H](OC(=O)[C@@H](O)[C@H](NC(=O)c4ccccc4)c4ccc(O)cc4)C(C)=C1C3(C)C)[C@@]1(OC(C)=O)CO[C@@H]1[C@H](O)[C@@H]2O
Technical inquiry about: SGI-1027
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