Simvastatin

CAS: 79902-63-9

Ref. TR-S485000

Product Information

• Name: Simvastatin
• Synonyms: Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (9CI), Cholestat, Denan, Eucor, Kolestevan, L 644128-000U, Lipex, Lipinorm, Liponorm, Lipovas, Lodales, MK 733, Modutrol, Nor-Vastina, Rechol, Simcor, Simovil, Simvastatin lactone, Simvotin, Sinvacor, Sinvascor, Sivastin, Statin, Synvinolin, Valemia, Velostatin, Zocor, Zocord, Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-, (+)-Simvastatin, Apo-Simva, Apo-Simvastatin, Bestatin 20, Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α,3α,7β,8β(2S*,4S*),8aβ]]-, Co-Simvastatin, Egilipid, Lycostatin, Mk 733, Novo-Simvastatin, Pms-simvastatin, Simastin 20, Simcovas, Simgal, Simi 20, Simlip, Simlip 20, Simlo 20, Simlup 20, Simratio, Simvacard, Simvachol, Simvacor, Simvahexal, Simvas, Simvasterol, Simvastol, Simvofix, Starstat 20, Vasilip, Vastan, Vazilip, Ximve, Zocor Forte, Zorced, Zosta

Description

Applications Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),

• Brand: TRC

Chemical properties

• Molecular weight: 418.57
• Formula: C₂₅H₃₈O₅
• Color/Form: White To Off-White
• InChI: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
• InChI key: InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N
• SMILES: CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21