Product Information
Name:rac-Talmapimod
Controlled Product
Synonyms:
- rel-6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
- SCIO 282
- SD 282
Brand:TRC
Description:
Applications rac-Talmapimod is a p38α-selective mitogen-activated protein kinase inhibitor, SD-282, to clinIcally used serum-free culture medium. By reducing interleukin 6 mRNA expression as well as IL-6, -8, granulocyte-macrophage colony-stimulating factor release and preventing β-cell apoptosis improved cultured human pancreatic islet cell recovery in serum-free medium. An α-isoform selective inhibitor for p38 MAP kinase
References Omori, K., et al.: Pancreas (Hagerstown, MD, United States), 39, 436 (2010); Koppelman, B., et al.: Pharmacology, 81, 204 (2008)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:513.0
Formula:C27H30ClFN4O3
Color/Form:Neat
InChI:InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1
InChI key:InChIKey=ZMELOYOKMZBMRB-DLBZAZTESA-N
SMILES:C[C@H]1CN(C(=O)c2cc3c(C(=O)C(=O)N(C)C)cn(C)c3cc2Cl)[C@H](C)CN1Cc1ccc(F)cc1
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